Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis

• Main Author: JOHNSON JR THEODORE O.,REICH SIEGFRIED HEINZ,CHAN FORA P.,CHU SHAO SONG,YANG YI,HUA YE,LUU HIEP THE,EASTMAN BRIAN WALTER,HENDRICKSON THOMAS F. ET AL. (U
• Format: Patent
• Language: Chinese; English
• Published: 01.09.2004
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

式(I)化合物(其中通式变量如说明书中定义)能够有效地抑制或阻断细小RNA病毒3C蛋白酶的生物活性。这些化合物及包含它们的药物组合物可用于治疗被一种或多种细小RNA病毒如RVP感染的患者或宿主。本发明还描述了制备此类化合物用的中间体与合成方法。 Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.