Triamide-substituted indoles, benzofuranes and benzothiophenes as inhibitors of microsomal triglyceride transfer protein (MTP) and/or apolipoprotein b (APO B) secretion

本发明涉及式1的三酰胺MTP/Apo B抑制剂，其中R#+[1]-R#+[8]如说明书中定义，并且还涉及其药物组合物和用途，以及制备该化合物的方法。本发明的化合物用于治疗肥胖症和类脂疾病。 The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparin...

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Bibliographic Details
Main Author HUATAN HIEP,MASON CLIVE,BRONK BRIAN S.,BERTINATO PETER,BLIZE ALAN E.,CHENG HENGMIAO,LI JIN
Format Patent
LanguageChinese
English
Published 18.08.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:本发明涉及式1的三酰胺MTP/Apo B抑制剂，其中R#+[1]-R#+[8]如说明书中定义，并且还涉及其药物组合物和用途，以及制备该化合物的方法。本发明的化合物用于治疗肥胖症和类脂疾病。 The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for preparing the compounds. The compounds of the invention are useful for the treatment of obesity and lipid disorders.
Bibliography:Application Number: CN20028013021