Pediatric formulation of gatifloxacin

本发明提供充分味道掩蔽使其能够应用于儿科制剂的喹诺酮抗菌药盖敌伏赛星，已经发现盖敌伏赛星与硬脂酸和棕榈酸之一或两者以窄重量比的结晶共沉淀可以有效掩蔽盖敌伏赛星的苦味。盖敌伏赛星在口腔内和含水混悬剂在整个给药周期、特别是14天内的味道被有效掩蔽。发现所结晶共沉淀中的盖敌伏赛星在胃内很容易被吸收利用。 There is provided in accordance with the present invention the quinolone antibacterial gatifloxacin adequately taste-masked so that it can be utilized...

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Bibliographic Details
Main Authors K.S. RAGHAVAN, S.A. RANADIVE, K.S. BEMBENEK
Format Patent
LanguageChinese
English
Published 04.08.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:本发明提供充分味道掩蔽使其能够应用于儿科制剂的喹诺酮抗菌药盖敌伏赛星，已经发现盖敌伏赛星与硬脂酸和棕榈酸之一或两者以窄重量比的结晶共沉淀可以有效掩蔽盖敌伏赛星的苦味。盖敌伏赛星在口腔内和含水混悬剂在整个给药周期、特别是14天内的味道被有效掩蔽。发现所结晶共沉淀中的盖敌伏赛星在胃内很容易被吸收利用。 There is provided in accordance with the present invention the quinolone antibacterial gatifloxacin adequately taste-masked so that it can be utilized for pediatric formulations. A crystalline co-precipitate of gatifloxacin and one or both of stearic acid and palmitic acid in a narrow weight ratio has been found to effectively mask the bitter taste of gatifloxacin. The taste of gatifloxacin is effectively masked in the mouth and in aqueous suspension through a full dosage cycle, typically fourteen days. Gatifloxacin in the subject crystalline co-precipitates has been found to be readily available for absorption from the stomach.
Bibliography:Application Number: CN20028012409