Carbamate compounds for use in preventing or treating neurodegenerative disorders

• Main Authors: C.R. PLATA-SALAMAN, R.E. TWYMAN, ZHAO BOYU
• Format: Patent
• Language: Chinese; English
• Published: 09.06.2004
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

本发明涉及预防或治疗神经变性疾病的方法，该方法包括给予其需要患者治疗有效量的选自式(I)和式(II)的化合物；其中苯基在X位置被1至5个选自氟、氯、溴和碘的卤素原子取代；R#-[1]、R#-[2]、R#-[3]、R#-[4]、R#-[5]和R#-[6]独立选自氢和C#-[1]-C#-[4]烷基；其中C#-[1]-C#-[4]烷基任选被苯基取代(其中苯基任选被独立选自卤素、C#-[1]-C#-[4]烷基、C#-[1]-C#-[4]烷氧基、氨基、硝基和氰基的取代基取代)。 This invention is directed to a method for preventing or treating neurodegenerative disorders comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): wherein phenyl is substituted at X with one to five halogen atoms selected from the group consisting of fluorine, chlorine, bromine and iodine; and, R1, R2, R3, R4, R5 and R6 are independently selected from the group consisting of hydrogen and C1-C4 alkyl; wherein C1-C4 alkyl is optionally substituted with phenyl (wherein phenyl is optionally substituted with substituents independently selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 alkoxy, amino, nitro and cyano).