Antiseptic composition of mezlocillin

• Main Author: YU ZHOU
• Format: Patent
• Language: Chinese; English
• Published: 31.03.2004
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

An antibiotic composition of meloxine, which is composed of meloxine andª‰-lactamase inhibitor at the weight ratio of 1-10í†10-1 based on the amount of active acids. meloxine is in the form of the alkali salt of meloxine or in the form of its free acid and solubility promoter; theª‰-lactamase inhibitor is clavulanic acid or tazobactam or their derivatives. Besides mixing and preparing beforehand,the composition could be prepared by mixing meloxine andª‰-lactamase inhibitor proportionally in clinical applications, then is administered, ormeloxine andª‰-lactamase inhibitor are administered independently. meloxine andª‰-lactamase inhibitor are synergetic, which could solve the problem of meloxine resistance in clinical applications. 本发明美洛西林抗菌组合药物，由半合成青霉素中的美洛西林与β-内酰胺酶抑制剂分别按活性酸重量比为1-10∶10-1组合而成。美洛西林为美洛西林的碱金属盐或其游离酸加助溶剂的形式；β-内酰胺酶抑制剂为克拉维酸、或他唑巴坦或它们的衍生物，如他唑巴坦钠、克拉维酸钾等。除事先混配成组合药物外，也可在临床用药时将美洛西林与β-内酰胺酶抑制剂按配比混合后给药或分别给药。本发明中的β-内酰胺酶抑制剂与美洛西林间具有显著的协同抗菌作用，有效解决了越来越多的临床致病菌对美洛西林产生耐药的问题。