Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same

• Main Authors: NAGYNE ARVAI EDIT, FORGACS ILONA, KERI VILMOS
• Format: Patent
• Language: Chinese; English
• Published: 14.01.2004
• Edition: 7
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; APPARATUS THEREFOR; BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

本发明提供了基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠，表普伐他汀为普伐他汀的C-6差向异构体。本发明进一步提供了从发酵肉汤中以高纯度回收普伐他汀钠的新方法。该方法包括通过萃取形成化合物的溶液，从溶液中得到普伐他汀铵盐，纯化该化合物的铵盐，并置换该化合物的盐至普伐他汀钠的步骤。 The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high purity. The process includes the stages of forming an solution of the compound by extraction, obtaining an ammonium salt of pravastatin from the solution, purifying the ammonium salt of the compound and transposing the salt of the compound to pravastatin sodium.