Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight

• Main Authors: GUSTAVSSON NILS OVE, LAAKSO TIMO, RESLOW MATS
• Format: Patent
• Language: Chinese; English
• Published: 14.01.2004
• Edition: 7
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR CHEMICAL WORKING-UP; THEIR RELEVANT APPARATUS; TRANSPORTING

一种制备可肠道外给药的微粒的方法，其中配制分子量被降低的、以支链淀粉为基础的至少20％重量的纯化淀粉水溶液，将此溶液与生物活性物质混合，形成淀粉液滴在聚合物溶液外相中的乳状液，使淀粉液滴变成凝胶，将胶凝的淀粉颗粒干燥。还可任选地向颗粒施涂一个控制释放的壳层。基本上由该淀粉组成的这些微粒的氨基酸含量少于50μg，而且没有共价化学交联。 A vaccine composition which comprises an immnunologically active substance embedded in microparticles essentially consisting of starch having an amylopectin content exceeding 85% by weight, of which at least 80% by weight has an average molecular weight within the range of 10-10000 kDa, and without any covalent chemical cross-linking between the starch molecules. A process for preparing such vaccine composition.