Cyclic amidine compounds

There is provided cyclic amidine compounds of the following formula (I): wherein: A1 and A2 are hydrogen atom, optionally substituted alkyl group; optionally substituted aryl group; or optionally substituted heterocyclic group; and X is -C(R1,R2)-C(R3,R4)-, -C(R5)=C(R6)-, -C(R7,R8)-C(R9,R10)-C(R11,R...

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Bibliographic Details
Main Authors IMOTO MASAHIRO, IWANAMI TATSUYA, AKABANE MINAKO
Format Patent
LanguageEnglish
Published 22.01.2003
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:There is provided cyclic amidine compounds of the following formula (I): wherein: A1 and A2 are hydrogen atom, optionally substituted alkyl group; optionally substituted aryl group; or optionally substituted heterocyclic group; and X is -C(R1,R2)-C(R3,R4)-, -C(R5)=C(R6)-, -C(R7,R8)-C(R9,R10)-C(R11,R12)-, or -C(R13,R14)-C(R15,R16)-NH- (wherein, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15 and R16 are hydrogen atom; halogen atom; optionally substituted alkyl group; optionally substituted aryl group; or optionally substituted heterocyclic group; or pharmaceutically acceptable salts thereof. These compounds have good affinity for alpha4beta2 nicotinic acetylcholine receptors and activate the same to thereby exert a preventive or therapeutic effect on cerebral dysfunction.
Bibliography:Application Number: CN20018000984