Platinum complex, its preparation and therapeutic application

• Main Authors: FRANTISEK ZCARON, ANNA POULOV, ADOLF MISTR
• Format: Patent
• Language: English
• Published: 11.07.2001
• Edition: 7
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A platinum complex of the general formula (I) wherein X represents a halogen atom and A represents a group -NH2-R wherein R is a tricyclic hydrocarbon moiety containing 10 to 14 carbon atoms which may be optionally substituted on the tricyclic ring by one or two alkyl group(s) containing 1 to 4 carbon atoms, and, furthermore, an inclusion complex of the above platinum complex with beta- or gamma-cyclodextrin which may be optionally substituted by a hydroxyalkyl group of 1 to 6 carbon atoms. There are also disclosed a method for the preparation of the complex of the formula (I) based on bringing into reaction a solution of an akaline metal salt of amminetrihalogenoplatinate (1-) in a polar organic solvent or in water with a primary amine of formula R-NH2, wherein R is a tricyclic hydrogen moiety containing 10 to 14 carbon atoms, which may be optionally substituted on the tricyclic ring by one or two alkyl group(s) each containing 1 to 4 carbon atoms, at the temperature in the range of 0 to 100° C., as well as a method for manufacture of the above inclusion complex. The both disclosed complexes may be used as such or as a part of pharmaceutical composition in a therapy of oncologic diseases.