Intermediates for the synthesis of benzimidazole compounds and process for preparation thereof

This invention provides a process for the preparation of a benzimidazole derivative (9) or a pharmaceutically acceptable salt thereof, by condensation of a compound of formula (6) with a compound of formula (7) in the presence of a condensing agent to afford a compound of formula (8), followed by, i...

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Bibliographic Details
Main Author KISHI NAOYUKI,NAKAMURA YOSHITAKA,ABE NARUMI
Format Patent
LanguageEnglish
Published 05.04.2006
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention provides a process for the preparation of a benzimidazole derivative (9) or a pharmaceutically acceptable salt thereof, by condensation of a compound of formula (6) with a compound of formula (7) in the presence of a condensing agent to afford a compound of formula (8), followed by, if necessary removal of the amino protecting group of compound (8), and then cyclization of compound (8) in the presence of an acid, wherein R , R , R and R are each independently hydrogen, hydroxyl, alkyl, alkoxy, benzyloxy, acetoxy, trifluoromethyl or halogen, R is alkyl and R is hydrogen or an amino protecting group, wherein R , R , R , R , R and R are as defined above, wherein R , R , R , R , and R are as defined above.
Bibliography:Application Number: CN20008011986