用于肾脏疾病的临床前和/或早期检测和/或诊断的生物标记物

• Format: Patent
• Language: Chinese
• Published: 12.08.2025
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

本发明涉及用于肾脏疾病的临床前和/或早期检测和/或诊断的生物标记物。特别地，提供了诸如选自XIII型胶原蛋白(COLXIII)、透明质酸结合蛋白2(HABP2)、C4结合蛋白(C4BP)、补体因子H(CFH)和补体因子I(CFI)的至少两种蛋白质的组合，在用于肾脏疾病的临床前和/或早期检测和/或诊断的方法中用作生物标记物。本发明还涉及一种用于肾脏疾病的临床前和/或早期检测和/或诊断的方法，该方法包括(a)测定受试者的样品中至少两种蛋白质的浓度，以及(b)将步骤(a)中测定的每种浓度与对照值进行比较，其中步骤(a)中测定的每种浓度与所述对照值的偏差指示临床前和/或早期肾脏疾病。 The present invention relates to biomarkers for the pre-clinical and/or early-stage detection and/or diagnosis of a kidney disease. In particular, a combination of at least two proteins such as selected from Collagen type XIII (COLXIII), Hyaluronan-Binding Protein 2 (HABP2), C4 Binding Protein (C4BP), Complement Factor H (CFH), and Complement Factor I (CFI) is provided for use as biomarker in a method for the pre-clinical and/or early-stage detection and/or diagnosis of a kidney disease. The present invention further relates to a method for the pre-clinical and/or early-stage detection and/or diagnosis of a kidney disease, comprising (a) determining the concentration of at least two proteins in a sample of a subject, and (