AAV制剂

• Format: Patent
• Language: Chinese
• Published: 01.08.2025
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

本公开提供了一种组合物，其包含重组腺相关病毒(AAV)载体、氯化钠、氯化钾、氯化镁、磷酸盐缓冲剂和非离子表面活性剂，pH为7.2-7.4，所述重组AAV载体包含异源核酸。本公开进一步提供了一种治疗受试者的神经系统病症的方法，所述方法包含向有需要的受试者的中枢神经系统直接施用所述组合物。 The disclosure provides a composition comprising recombinant adeno-associated virus (AAV) vectors comprising a heterologous nucleic acid, sodium chloride, potassium chloride, magnesium chloride, phosphate buffer, and a non-ionic surfactant, at pH of 7.2-7.4. The disclosure further provides a method of treating a neurological disorder in a subject, the method comprising directly administering to the central nervous system of a subject in need thereof the composition.