Application of detection reagent in preparation of diagnostic tool for diagnosing or monitoring AD

• Main Authors: QU XUEQI, CHEN YU, CHEN YUEWEN
• Format: Patent
• Language: Chinese; English
• Published: 24.06.2025
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

The invention belongs to the technical field of biology, and provides application of a reagent for detecting the concentration of immune cells and immune factors in peripheral circulating cerebrospinal fluid in preparation of a diagnostic tool or a treatment tool for diagnosing or monitoring AD (Alzheimer's disease). Clinical diagnosis of AD occurrence and development is performed by detecting biomarkers in blood, so that the diagnosis cost is reduced, the operation is easy, and the risk of central infection in the intracerebral sampling process of a subject is avoided. 本发明属于生物技术领域，提供了一种检测外周循环脑脊液中免疫细胞和免疫因子的浓度的试剂在制备用于诊断或者监测AD的诊断工具或治疗工具中的应用。通过检测血液中生物标志物进行AD发生发展的临床诊断不仅降低了诊断成本，而且容易操作，避免了受检者脑内取样过程中感染中枢风险。