Photoresponsive peptide delivery systems and methods of use thereof

• Main Authors: WANG WEIPING, LIANG XIAOLING, LI JIA, ZHOU YANG
• Format: Patent
• Language: Chinese; English
• Published: 06.06.2025
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are photoresponsive prodrugs comprising an active agent conjugated to a photoresponsive group, and nanoparticles formed in which a photoresponsive prodrug is co-assembled with a polymer. Also provided are methods of treating a subject comprising administering a photoresponsive prodrug or nanoparticle to the subject and irradiating a target site with a light source. 本文提供了包含缀合至光响应基团的活性剂的光响应性前药，以及其中光响应性前药与聚合物共组装而形成的纳米颗粒。还提供了治疗受试者的方法，包括向受试者施用光响应性前药或纳米颗粒，并用光源照射目标部位。