Method for evaluating biological activity of pulmonary surfactant

• Main Authors: LIU BIN, LI XIAOYI, SUN YUE, HUANG SIJIA, WANG NIAN
• Format: Patent
• Language: Chinese; English
• Published: 02.05.2025
• Subjects: DIAGNOSIS; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MEDICAL OR VETERINARY SCIENCE; SURGERY; VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS

The invention relates to the technical field of drug efficacy and activity testing, and discloses a pulmonary surfactant biological activity evaluation method. According to the method for evaluating the biological activity of the pulmonary surfactant, a young rabbit lacking the pulmonary surfactant is selected as an experimental subject, the improvement effect of the tested pulmonary surfactant on the pulmonary respiration compliance value of the young rabbit is detected through pulmonary drug delivery, and whether the drug effect and the biological activity of the drug meet the requirements or not is evaluated according to the experimental data result. The method has the advantages of high accuracy, repeatability and sensitivity, simple operation steps and wide applicability. 本申请涉及药物药效及活性测试技术领域，公开了一种肺表面活性剂生物活性的评价方法。本申请提供的肺表面活性剂生物活性的评价方法，选择肺表面活性剂缺失的幼兔为实验对象，通过肺部给药检测所测受试肺表面活性剂对幼兔肺呼吸顺应值的改善作用，根据实验数据结果评价药物药效及生物活性是否满足要求，该方法具有较高的准确性、重复性和灵敏度，操作步骤简单，适用性广泛。