Process for preparation of pyrazolo pyridazine derivatives

A process for the preparation of a compound of formula (I)and pharmaceutically acceptable derivatives thereof in which:R is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR R ;R and R are independently selected from H, C1-6alkyl, C1-6alkyl substitute...

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Bibliographic Details
Main Authors NEIL MATHEWS, ANDREW J. WHITEHEAD, RICHARD A. WARD
Format Patent
LanguageEnglish
Published 20.04.2005
Edition7
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A process for the preparation of a compound of formula (I)and pharmaceutically acceptable derivatives thereof in which:R is halogen, C1-6alkyl, C1-6alkoxy, C1-6alkoxy substituted by one or more fluorine atoms, or O(CH2)nNR R ;R and R are independently selected from H, C1-6alkyl, C1-6alkyl substituted by one or more fluorine atoms, C1-6alkoxy, C1-6hydroxyalkyl, SC1-6alkyl, C(O)H, C(O)C1-6alkyl, C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR R , (CH2)nSC1-6alkyl or C(O)NR R ; with the proviso that when R is at the 4-position and is halogen, at least one of R and R is C1-6alkylsulphonyl, C1-6alkoxy substituted by one or more fluorine atoms, O(CH2)nCO2C1-6alkyl, O(CH2)nSC1-6alkyl, (CH2)nNR R or (CH2)nSC1-6alkyl, C(O)NR R ;R is C1-6alkyl or NH2;R and R are independently selected from H, or C1-6alkyl or, together with the nitrogen atom to which they are attached, form a 4-8 membered saturated ring; andn is 1-4.
Bibliography:Application Number: CN20008017658