Sphingolipid-loaded nano biological preparation for immunomodulation

• Main Authors: FAYAD, ZAHID, A, THEUNISSEN, ADRIANUS, J, DEAVENWORTON, RICHARD, MULDER, WILLEM, J
• Format: Patent
• Language: Chinese; English
• Published: 14.03.2025
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein is a sphingolipid loaded nanobiologic, comprising: an apolipoprotein A-1 (apoA-1) or a peptidomimetic of apoA-1; sphingolipid; the present invention relates to a nanobiological composition, and cholesterol, and uses thereof, for example, including methods of stimulating innate immune modulation of a training immune response in a subject, and methods of treating cancer, comprising administering the nanobiological composition. 本文提供的是负载鞘脂的纳米生物制剂，其包括：载脂蛋白A-1(apoA-1)或apoA-1的肽模拟物；鞘脂；和胆固醇，并提供其用途，例如，包括刺激受试者的训练免疫应答的先天免疫调节的方法，以及治疗癌症的方法，所述方法包括施用纳米生物组合物。