RNA adjuvants, methods and uses thereof

Provided herein are adjuvants, compositions, and methods for the prevention and treatment of infectious diseases and cancer. Provided herein are various toll-like receptor (TLR) agonists and RNAs encoding the TLR agonists. The adjuvants provided herein can be compounded with a carrier or formulated...

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Bibliographic Details
Main Authors GITLIN ILYA, ANDRIANOVA EKATERINA LEONIDOVNA
Format Patent
LanguageChinese
English
Published 25.02.2025
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided herein are adjuvants, compositions, and methods for the prevention and treatment of infectious diseases and cancer. Provided herein are various toll-like receptor (TLR) agonists and RNAs encoding the TLR agonists. The adjuvants provided herein can be compounded with a carrier or formulated with a delivery vehicle for administration to a subject. Also provided are adjuvants that can be delivered with or as part of a vaccine composition to enhance an innate immune response in a subject. 本文提供了用于预防和治疗感染性疾病和癌症的佐剂、组合物和方法。本文提供了各种toll样受体(TLR)激动剂和编码TLR激动剂的RNA。本文提供的佐剂能够与载剂复合或与递送媒介物一起配制以用于施用于受试者。还提供了能够与疫苗组合物一起递送或作为疫苗组合物的部分递送以增强受试者的先天免疫应答的佐剂。
Bibliography:Application Number: CN20238048480