PH response type anti-adhesion antibacterial nanorod coating based on bacteriophage endolysin

The invention discloses a pH response type nanorod intelligent antibacterial coating constructed on the surface of stainless steel for the first time. According to the coating, stimuli-responsive polymer polyacrylic acid (PAA) and phage-derived endolysin Lys81 are grafted to a ZnO nano-column, and s...

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Bibliographic Details
Main Authors LI HEXUE, SHI HUI
Format Patent
LanguageChinese
English
Published 07.02.2025
Subjects
ADHESIVES
APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL
BEER
BIOCHEMISTRY
CHEMICAL PAINT OR INK REMOVERS
CHEMISTRY
COATING COMPOSITIONS, e.g. PAINTS, VARNISHES ORLACQUERS
COMPOSITIONS THEREOF
CORRECTING FLUIDS
CULTURE MEDIA
DYES
ENZYMOLOGY
FILLING PASTES
INKS
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MISCELLANEOUS APPLICATIONS OF MATERIALS
MISCELLANEOUS COMPOSITIONS
MUTATION OR GENETIC ENGINEERING
NATURAL RESINS
PAINTS
PASTES OR SOLIDS FOR COLOURING OR PRINTING
PERFORMING OPERATIONS
POLISHES
PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
SPRAYING OR ATOMISING IN GENERAL
TRANSPORTING
USE OF MATERIALS THEREFOR
VINEGAR
WINE
WOODSTAINS
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Summary:The invention discloses a pH response type nanorod intelligent antibacterial coating constructed on the surface of stainless steel for the first time. According to the coating, stimuli-responsive polymer polyacrylic acid (PAA) and phage-derived endolysin Lys81 are grafted to a ZnO nano-column, and self-regulation is carried out in response to environmental conditions. In the initial stage of bacterial adhesion, the surface of the nanorod shows remarkable mechanical bactericidal activity, and the bacterial adhesion is effectively inhibited by the super-hydrophilic PAA layer. In a later stage, when many live bacteria and dead bacteria adhere to the surface of the nanorod, the PAA chain disintegrates, exposing the endolysin bottom layer that lyses the damaged bacteria. In addition, along with the increase of the pH value of the environment, the attached dead bacteria can be released once the hydrophilicity of the PAA chain is recovered. The purpose of the present invention is to apply an antibacterial coating to
Bibliography:Application Number: CN202411512214