COMPOSITIONS AND METHODS FOR TREATING CANCER WITH ANTI-CD123 IMMUNOTHERAPY

Chimeric antigen receptors comprising a CD123 antigen binding domain are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments and pharmaceutical compositions relating to the chimeric antigen receptors are also disclosed. Also disclosed are methods of treati...

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Bibliographic Details
Main Authors BARRY RAPHAEL, TOMCZAK, FLORIAN, ZHU ZHONGYU, SCHNEIDER DINA
Format Patent
LanguageChinese
English
Published 31.12.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Chimeric antigen receptors comprising a CD123 antigen binding domain are disclosed. Nucleic acids, recombinant expression vectors, host cells, antigen binding fragments and pharmaceutical compositions relating to the chimeric antigen receptors are also disclosed. Also disclosed are methods of treating or preventing cancer in a subject, as well as methods of preparing chimeric antigen receptor T cells. 公开了包含CD123抗原结合结构域的嵌合抗原受体。还公开了涉及所述嵌合抗原受体的核酸、重组表达载体、宿主细胞、抗原结合片段和药物组合物。还公开了在对象中治疗或预防癌症的方法，以及制备嵌合抗原受体T细胞的方法。
Bibliography:Application Number: CN20238031951