New application of melanocortin-1 receptor agonist

• Main Authors: KONDO MASAHIRO, KONO YUKO, SUZUKI TSUYOSHI
• Format: Patent
• Language: Chinese; English
• Published: 10.09.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to a medicament for treating or preventing interstitial lung disease and diseases or symptoms associated with systemic sclerosis in a subject, the present invention relates to a pharmaceutical composition containing, as an active ingredient, 1-{2-[(3S, 4R)-1-{[(3R, 4R)-1-cyclopentyl-3-fluoro-4-(4-methoxyphenyl) pyrrolidin-3-yl] carbonyl}-4-(methoxymethyl) pyrrolidin-3-yl]-5-(trifluoromethyl) phenyl} piperidine-4-carboxylic acid, or a pharmaceutically acceptable salt or co-crystal thereof. 本发明涉及用于治疗或预防对象的间质性肺疾病及与系统性硬化病相伴的疾病或症状的药物，其以1-{2-[(3S,4R)-1-{[(3R,4R)-1-环戊基-3-氟-4-(4-甲氧基苯基)吡咯烷-3-基]羰基}-4-(甲氧基甲基)吡咯烷-3-基]-5-(三氟甲基)苯基}哌啶-4-甲酸或者其药学上可接受的盐或共晶作为有效成分。