Molecular target combination containing dipeptide and application thereof

• Main Author: LI BIN
• Format: Patent
• Language: Chinese; English
• Published: 10.09.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The invention discloses a molecular target combination containing dipeptide and application of the molecular target combination. A specific molecular target combination and autoimmune cells of a subject are co-cultured and then are transfused back into the body of the subject, so that targeted killing of tumor cells is realized, and the purpose of treating tumors is achieved. The dendritic cell (DC) load positive rate activated by the molecular target combination is greater than 90%. Furthermore, the activated DC cells highly express CD80 and CD86 on the surface and are presented to T lymphocytes, so that the activated DC cells become MCTL cells for specifically recognizing lung cancer cells. 本发明公开了一种含有双肽的分子靶标组合及其用途。将特异性分子靶标组合与受试者自体免疫细胞共同培养，然后回输至受试者体内，以实现对肿瘤细胞的有针对性杀伤，从而达到治疗肿瘤的目的。本发明的分子靶标组合活化的树突状细胞(DC)负载阳性率大于90％。进一步地，这些被活化的DC细胞在表面高表达CD80和CD86，并将其呈递至T淋巴细胞，使其成为特异性识别肺癌细胞的MCTL细胞。