SARS-COV-2 RNA vaccine compositions and methods of use

• Main Authors: BERGLUND LARS PETER AXEL, ARCHER JACOB FREEMAN, REED STEVEN GREGORY, CARTER DARRICK ALBERT, KAMDAR AMIT PRAVL, ERASMUS, JESSE, DUSSEY, MALCOLM, S, BERUBE, BRIAN
• Format: Patent
• Language: Chinese; English
• Published: 06.09.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present disclosure provides compositions, methods of treatment, and methods of making and using the compositions to deliver nucleic acids to a subject. The compositions described herein comprise a lipid carrier, optionally comprising inorganic particles capable of being mixed with a nucleic acid. Also provided are methods of using the compositions as COVID-19 vaccines for the treatment of coronavirus infections. 本公开内容提供了组合物、治疗方法以及制备并使用组合物以将核酸递送至受试者的方法。本文描述的组合物包含脂质载体，任选地包含能够与核酸混合的无机颗粒。还提供了使用该组合物作为COVID-19疫苗用于治疗冠状病毒感染的方法。