Preparation method of flexible microneedle electrode based on regenerated silk fibroin

• Main Authors: CHEN YANGYANG, LIU XUAN, GUO WENXI
• Format: Patent
• Language: Chinese; English
• Published: 03.09.2024
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DIAGNOSIS; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; SURGERY; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS; WORKING-UP

The invention discloses a preparation method of a flexible microneedle electrode based on regenerated silk fibroin. The preparation method comprises the following steps: 1) preparing a regenerated silk fibroin solution; 2) adding a waterborne polyurethane solution, a silver nanowire dispersion liquid and a cross-linking agent into the regenerated silk fibroin solution, uniformly mixing, and then cross-linking; and 3) pouring the cross-linked mixed solution into a PDMS mold containing a needle-like micropore array, removing bubbles in the solution under a certain vacuum degree, drying in a drying oven, and demolding to obtain the regenerated silk fibroin microneedle electrode. The microneedle electrode has good flexibility and good biocompatibility, and has a wide application prospect in the fields of skin-attached electronic devices and the like. 一种基于再生丝素蛋白的柔性微针电极制备方法，包括以下步骤：1)制备再生丝素蛋白溶液；2)在再生丝素蛋白溶液中加入水性聚氨酯溶液、银纳米线分散液以及交联剂混合均匀后交联；3)将交联后的混合溶液倒入含有针状微孔阵列的PDMS模具中，在一定真空度下去除溶液中的气泡，在烘箱中干燥后脱模，得到再生丝素蛋白微针电极。此微针电极具有良好的柔韧