AAV vector for coding anti-VEGF-A and ANG-2 bispecific antibody

• Main Authors: CAI YUAN, MA ZHEN, ZHAO JIN, ZHANG MINGLIANG, ZHOU PEIPEI
• Format: Patent
• Language: Chinese; English
• Published: 30.08.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Provided are a bispecific antibody, an encoding nucleic acid thereof, an AAV virus vector comprising the nucleic acid, and a virus particle. Also provided are pharmaceutical compositions comprising the bispecific antibodies, encoding nucleic acids, AAV viral vectors or viral particles. The bispecific antibody comprises a binding domain specific for VEGF-A and ANG-2, and can be used for treating wet age-related macular degeneration or diabetic macular edema in a subject. 提供了一种双特异性抗体、其编码核酸、包含该核酸的AAV病毒载体和病毒颗粒。还提供了包含该双特异性抗体、编码核酸、AAV病毒载体或病毒颗粒的药物组合物。该双特异性抗体包含特异于VEGF-A和ANG-2的结合结构域，可用于治疗受试者的湿性年龄相关性黄斑变性或糖尿病性黄斑水肿。