Anti-PILRA antibodies, uses thereof, and related methods and reagents

• Main Authors: MONROE KATHRYN M, YOUNG ALEXANDER, PARKER JOSHUA I, SABELSTRU M, HANNA, KIM DO-JIN, LIZINGO KATHERINE, DA ROZA CLAIRE, PROPSON NICHOLAS E, VELACODI TANYA N, TEOLIS, RICHARD, JR, MACDONALD MADELEINE
• Format: Patent
• Language: Chinese; English
• Published: 30.08.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Provided herein are anti-PILRA antibodies having highly desirable selectivity: comparable binding to machin and human PILRA proteins, but much weaker binding to human PILRB proteins, and binding to both PILRA G78 and R78 variants. The binding and selectivity profiles of the antibodies described herein allow them to be used in animal studies (e.g., monkeys) without relying on alternative molecules, and may also be used in treating a subject with any PILRA variant. The biological discovery associated with PILRA and the effect of reducing PILRA signaling in cells are further described herein for the first time. 本文提供了具有高度期望的选择性的抗PILRA抗体：与食蟹猴和人类PILRA蛋白具有相当的结合，但与人类PILRB蛋白的结合弱得多，以及与PILRA G78和R78变体两者的结合。本文描述的抗体的结合和选择性概况允许它们用于动物研究(例如，猴子)，而无需依赖于替代分子，并且也可以在用任一PILRA变体治疗受试者时使用。本文首次进一步描述了与PILRA相关的生物学发现以及减少细胞中PILRA信号传导的作用。