Nano-particle taking PEG10 protein as carrier as well as preparation method and application of nano-particle

The invention provides a nanoparticle for loading and/or delivering polypeptide by taking a PEG10 short homologous isomer as a carrier as well as a preparation method and application of the nanoparticle. The nanoparticle is formed by coupling and self-assembling a first recombinant protein containin...

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Bibliographic Details
Main Authors CHEN WEI, ZHAO XIAOFAN, YI MENGRAN, XU JUNJIE, LI YU, ZHANG JUN, LI YAOHUI, YANG YILONG
Format Patent
LanguageChinese
English
Published 30.08.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides a nanoparticle for loading and/or delivering polypeptide by taking a PEG10 short homologous isomer as a carrier as well as a preparation method and application of the nanoparticle. The nanoparticle is formed by coupling and self-assembling a first recombinant protein containing the PEG10 short homologous isomer and a second recombinant protein containing the loaded and/or delivered polypeptide. The invention also provides application of the nanoparticles in preparation of vaccines and intracellular therapeutic drugs. The nanoparticle delivery mode antigen provided by the invention can activate and generate efficient immune response, is expected to be used as a safe, universal and efficient endogenous recombinant protein delivery carrier, and improves the safety and immunospecificity of delivered vaccines. 本发明提供了一种以PEG10短同源异构体作为载体荷载和/或递送多肽的纳米颗粒及其制备方法和应用，所述纳米颗粒是由含PEG10短同源异构体的第一重组蛋白与含被荷载和/或递送的多肽的第二重组蛋白相偶联并自组装形成的纳米颗粒。本发明还提供了所述纳米颗粒制备疫苗和细胞内治疗药物的应用。本发明提供的纳米颗粒递送模式抗原能够激活产生高效的免疫反应，有望作为一种安全、通用、高效的
Bibliography:Application Number: CN20241145260