Application of 14, 15-epoxy eicosatrienoic acid in preparation of medicine for treating traumatic brain injury

• Main Authors: ZHU MINZHEN, ZHU XINHONG, DONG JINGHUA, DAI YONGFENG
• Format: Patent
• Language: Chinese; English
• Published: 30.08.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The invention discloses an application of 14, 15-epoxy eicosatrienoic acid in preparation of a medicine for treating traumatic brain injury. The 14, 15-epoxy eicosatrienoic acid wound cleaning agent is directly applied to brain tissue exposed to traumatic brain injury, or the 14, 15-epoxy eicosatrienoic acid wound cleaning agent and an sEH inhibitor are combined for treatment, the nerve protection effect on the injured brain tissue is achieved, and the problems that a nerve protection medicine difficultly penetrates through a blood brain barrier, cannot target a focus and cannot be used for treating traumatic brain injury are solved. The technical problems that nerve injury cannot be effectively relieved or repaired and effects after brain injury cannot be effectively improved are solved, and the technical problems that a nerve protection medicine quickly and directly acts on brain tissues in an injured area, the medicine preparation difficulty is reduced and side effects are reduced are solved. The neuroprot