Pentapeptides and uses thereof

• Main Authors: LI ZHEMIN, KIM HAE JIN, MOON EUN JOUNG, HAN YUN-HEE
• Format: Patent
• Language: Chinese; English
• Published: 23.08.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a pentapeptide formed by acetylating the N-terminus of a peptide comprising the amino acid sequence represented by SEQ ID NO: 1, a pharmaceutically acceptable salt thereof, and a use thereof. The pentapeptide is stable and effective for inhibiting resistance to anti-cancer drugs, inhibiting autophagy in tumor cells, enhancing immunity, activating immune cells, promoting anti-tumor immune response and/or anti-cancer treatment. 本发明提供通过乙酰化由SEQ ID NO：1所示的氨基酸序列组成的肽的N-末端而形成的五肽及其药学上可接受的盐，以及其用途。该五肽对于抑制抗癌药物抗性、在肿瘤细胞中抑制自噬、增强免疫力、活化免疫细胞、促进抗肿瘤免疫应答和/或抗癌治疗是稳定且有效的。