Etoderm mesenchymal stem cells and methods of producing same

• Main Authors: TAMAI KATSUTO, SHIMBO TAKASHI, YAMAZAKI TAKEHIKO, SASAKI HIDETSUGU
• Format: Patent
• Language: Chinese; English
• Published: 09.08.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The inventors found that ectoderm mesenchymal stem cells circulating in peripheral blood induced by necrotic tissue injury contribute to regeneration of injured tissues. Based on this discovery, provided are ectodermal mesenchymal stem cells, a method for producing the same, and a method for screening a substance having pluripotent stem cell-inducing activity using, as an indicator, cells induced by necrotic tissue damage in peripheral blood. 本发明人发现由坏死组织损伤诱导的外周血中循环的外胚层间充质干细胞有助于损伤组织的再生。基于该发现，提供了外胚层间充质干细胞、其产生方法以及具有多能干细胞诱导活性的物质的筛选方法，所述筛选方法使用外周血中的由坏死组织损伤诱导的细胞作为指标。