8-azaquinazolines as brain penetration SOS1 inhibitors

• Main Authors: GIOVANNINI RICCARDO, HEINE NIKLAS, HORN CARINA, MUEHLE STEPHAN G, RAMHARTER JUERGEN, WUNBERG TOBIAS
• Format: Patent
• Language: Chinese; English
• Published: 02.08.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to small molecules and salts thereof capable of inhibiting SOS1 (none of seven ions). In particular, the present invention relates to a heterocyclic compound of general formula (I) or a salt thereof, in which A, X, R1, R2 and R3 have one of the meanings as shown in the...