8-azaquinazolines as brain penetration SOS1 inhibitors

The present invention relates to small molecules and salts thereof capable of inhibiting SOS1 (none of seven ions). In particular, the present invention relates to a heterocyclic compound of general formula (I) or a salt thereof, in which A, X, R1, R2 and R3 have one of the meanings as shown in the...

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Bibliographic Details
Main Authors GIOVANNINI RICCARDO, HEINE NIKLAS, HORN CARINA, MUEHLE STEPHAN G, RAMHARTER JUERGEN, WUNBERG TOBIAS
Format Patent
LanguageChinese
English
Published 02.08.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to small molecules and salts thereof capable of inhibiting SOS1 (none of seven ions). In particular, the present invention relates to a heterocyclic compound of general formula (I) or a salt thereof, in which A, X, R1, R2 and R3 have one of the meanings as shown in the specification. In addition, the present invention relates to pharmaceutical compositions and combinations comprising these compounds and their use in methods of treating diseases associated with SOS1 or modulated by SOS1. # imgabs0 # 本发明涉及能够抑制SOS1(无七之子)的小分子及其盐。特别地，本发明涉及通式(I)的杂环化合物或其盐，其中A、X、R1、R2、R3具有如说明书中所示的含义中的一种。此外，本发明涉及包含这些化合物的药物组合物和组合及其在治疗与SOS1相关或受SOS1调节的疾病的方法中的用途。#imgabs0#
Bibliography:Application Number: CN20228084765