Preparation method of 4-bromomethyl quinolinone

The invention discloses a preparation method of 4-bromomethyl quinolinone, which comprises the following steps: S1, preparing 4-bromo-acetoacetanilide, dissolving the 4-bromo-acetoacetanilide in a toluene organic solvent with the volume 3-8 times that of the 4-bromo-acetoacetanilide, cooling to room...

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Bibliographic Details
Main Authors SHI YING, GAO RUIMIN, WANG XINFEI, XIANG FENG
Format Patent
LanguageChinese
English
Published 02.08.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a preparation method of 4-bromomethyl quinolinone, which comprises the following steps: S1, preparing 4-bromo-acetoacetanilide, dissolving the 4-bromo-acetoacetanilide in a toluene organic solvent with the volume 3-8 times that of the 4-bromo-acetoacetanilide, cooling to room temperature, dropwise adding 1-2.5 equivalent weight of cyclization reagent, and stirring for 12 hours after dropwise adding; s2, adding water with the volume 3 times that of the water for quenching reaction, adding sodium carbonate to adjust the pH value to 6-7, centrifuging, washing with water and drying to obtain 4-bromomethyl quinolinone; according to the preparation method disclosed by the invention, toluene is selected as a series of preferable organic solvents and a cyclization reagent of a boron trifluoride diethyl etherate complex, the 4-bromomethyl quinolinone is obtained at high yield, 4-5 tons of neutral wastewater is generated when one ton of product is produced, and the defects of large amounts of su
Bibliography:Application Number: CN202410474730