Indazole ether compound as well as preparation method and application thereof

• Main Authors: LI HONG, WU HAIXIA, XING YUXUAN, ZHANG ZHIGUANG, WANG HUIMING, ZHU ZHONGYANG, ZHAI PENGDA, GAO JINLONG, MA KAILE, XIA LIJIA, WANG YONG
• Format: Patent
• Language: Chinese; English
• Published: 26.07.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of novel compounds, and particularly discloses an indazole ether derivative as well as a preparation method and application thereof. The invention provides an indazole ether derivative with a novel structure, an indazole group with good activity is used as a parent nucleus structure, active groups such as N-methylpyridone, an amide group and a specific fluorine-containing functional group are introduced to a side chain of the indazole group, and the biological activity of the compound is effectively improved, so that the indazole ether derivative has a good application prospect. The invention not only enriches the types of the indazole ether compounds, but also provides a new compound for developing a novel glucocorticoid receptor modulator, and has very important significance for researching the activity of the indazole ether compounds and expanding the application of the compounds in drug synthesis. And a basis is provided for researching the glucocorticoid recep