Method of providing implantable hydrogel material and implantable hydrogel material

• Main Author: RAFAT, MEHRDAD
• Format: Patent
• Language: Chinese; English
• Published: 23.07.2024
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

Implantable collagen-based hydrogel materials are manufactured by providing a solution having a concentration of collagen molecules of 0.1 to 30% by weight and a concentration of cellulose nanofibers of 0 to 30% by weight. A non-polymeric short-range carbodiimide cross-linking agent is added to the solution in a concentration of 1 to 30 wt%, and riboflavin in a concentration of 0.1 to 10 wt%. The solution is allowed to react to form an intermediate hydrogel material, after which the intermediate hydrogel material is exposed to ultraviolet A light to form an implantable hydrogel material. 通过提供具有0.1至30重量％的胶原分子浓度和0至30重量％的纤维素纳米纤维浓度的溶液，制造可植入胶原基水凝胶材料。向所述溶液添加呈1-30重量％的浓度的非聚合型短程碳二亚胺交联剂，以及呈0.1至10重量％的浓度的核黄素。允许所述溶液反应，形成中间水凝胶材料，此后使所述中间水凝胶材料暴露于紫外A光，形成可植入水凝胶材料。