Targeted EGFR (epidermal growth factor receptor) cyclic peptide PET (positron emission tomography) developer as well as preparation method

The invention belongs to the field of pharmacy, and particularly relates to an EGFR-targeted tumor PET developer as well as a preparation method and application thereof. The invention provides a precursor of an EGFR (epidermal growth factor receptor)-targeted cyclopeptide PET (positron emission tomo...

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Bibliographic Details
Main Authors JIANG WENHAO, HUANG XIAOHONG, HUANG SHUN, SHI DAZHI, BAI LU
Format Patent
LanguageChinese
English
Published 23.07.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention belongs to the field of pharmacy, and particularly relates to an EGFR-targeted tumor PET developer as well as a preparation method and application thereof. The invention provides a precursor of an EGFR (epidermal growth factor receptor)-targeted cyclopeptide PET (positron emission tomography) developer and a preparation method of the precursor. The EGFR-targeted cyclopeptide PET developer can be prepared from the precursor. The EGFR-targeted PET imaging agent has excellent pharmacokinetic characteristics, good in-vivo and in-vitro stability, strong hydrophilicity, simple and convenient preparation method, high yield, capability of being specifically combined with various tumors with high EGFR expression, fast blood removal in organisms, mainly kidney excretion and clear PET imaging tumor display, and has the prospect of being widely applied to EGFR positive tumor diagnosis and treatment. 本发明属于制药领域，具体涉及靶向EGFR的肿瘤PET显像剂及其制备方法与应用。本发明提供一种靶向EGFR的环肽PET显像剂的前体及其制备方法，可由该前体制备靶向EGFR的环肽PET显像剂。该靶向EGFR的PET显像剂具
Bibliography:Application Number: CN202410612734