Application of lobetyolin in preparation of medicine for preventing or treating sepsis

• Main Authors: HE JIA, YE HUAIZHUANG, SONG IN-KYEONG, WEI QIAOHUI, XU YUYING
• Format: Patent
• Language: Chinese; English
• Published: 23.07.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an application of lobetyolin in preparation of a medicine for preventing or treating sepsis, and relates to the technical field of biological medicines, and the technical key points are as follows: by constructing an LPS (Lipopolysaccharide)-induced acute sepsis model, the lobetyolin is subjected to experimental research in the aspect of preventing and/or treating sepsis; the result shows that the lobetyolin has a good protective effect on the LPS-induced sepsis, is small in side effect and can be used for preparing the protective medicine for treating or preventing the sepsis. The invention provides a new application of lobetyolin in preparation of drugs for treating sepsis, and the lobetyolin has obvious effects in improving tissue damage and playing an anti-inflammatory effect, and has small side effects. 本发明公开了党参炔苷在制备预防或治疗脓毒症药物中的应用，涉及生物医药技术领域，其技术要点为：本发明通过构建LPS诱导的急性脓毒症模型，对党参炔苷在预防和/或治疗脓毒症方面进行实验研究，结果显示党参炔苷对LPS诱导脓毒症具有良好的保护作用，且副作用小，可用于制备治疗或预防脓毒症的保护性药物。本发明提供了党参炔苷在制备治疗脓毒症药物中的新用途，改善组织损伤、发挥