Antibodies binding to CD3 and PLAP

• Main Authors: CABI GUTIERREZ SIROS, ALEJANDRO, HOFER KLAUS, KUEHNLE THOMAS, HOFER THOMAS, FREIMOSER-GUNSCHER ANNIKA, BRANCH ANDREW, MOESSNER EKKEHARD, NEUMANN CHRISTIAN
• Format: Patent
• Language: Chinese; English
• Published: 19.07.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates generally to antibodies that bind to CD3 and PLAP, e.g., for activating T cells. In addition, the invention relates to polynucleotides encoding such antibodies, as well as vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing said antibodies and to methods of using said antibodies in the treatment of disease. 本发明总体上涉及与CD3和PLAP结合的、例如用于活化T细胞的抗体。此外，本发明涉及编码此类抗体的多核苷酸，以及包含此类多核苷酸的载体和宿主细胞。本发明进一步涉及用于产生所述抗体的方法，以及涉及在疾病的治疗中使用所述抗体的方法。