Hematological systems and methods

• Main Authors: WANDERS BART J, CREMINS JACK, FARRELL GREGORY A, ADAMS THOMAS H, QUON CAROL, GRONER WOLFGANG, ZHAO XIAODONG, JORDAN BRIAN
• Format: Patent
• Language: Chinese; English
• Published: 19.07.2024
• Subjects: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PHYSICS; TESTING

Aspects and embodiments of the present invention provide particle and/or intracellular organelle alignment agents for use by a particle analyzer for analyzing particles contained in a sample. Exemplary particle and/or intracellular organelle alignment agents include an aqueous solution, a viscosity modifier, and/or a buffer. Embodiments also encompass systems, compositions, and methods for analyzing a sample comprising particles. Particles, such as blood cells, may be classified and counted by a digital image processor. A digital microscope camera may be directed into a flow cell that defines a symmetrically narrowing flow path, where the sample stream flows in the form of a band that flattens between sheath fluid layers due to flow and viscosity parameters, for example, using certain focusing techniques. Blood cell images may be acquired and analyzed using dynamic range extension methods and systems. 本发明的各方面和实施例提供了粒子和/或细胞内细胞器配向剂，该配向剂供用来分析样品中所含的粒子的粒子分析仪使用。示例性粒子和/或细胞内细胞器配向剂包含水溶液、粘度改性剂和/或缓冲剂。实施例还涵盖用于分析包含粒子的样品的系