Protein arginine methyltransferase inhibitors

The invention relates to inhibitors of protein arginine methyltransferase. Specifically, the invention relates to a compound shown in a general formula (I), a preparation method of the compound, a pharmaceutical composition containing the compound and application of the compound as a PRMT5 inhibitor...

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Bibliographic Details
Main Authors ZHOU YIMIN, ZONG LIBIN, ZHENG YI, CHEN SHIZHU, REN YUE, LIU GUOBIAO, LI BIN, YAN XU, LIU DING, DU PEIJIN
Format Patent
LanguageChinese
English
Published 19.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to inhibitors of protein arginine methyltransferase. Specifically, the invention relates to a compound shown in a general formula (I), a preparation method of the compound, a pharmaceutical composition containing the compound and application of the compound as a PRMT5 inhibitor. The compound and the pharmaceutical composition containing the compound can be used for treating and/or preventing diseases related to PRMT5 activity, such as cancers. Wherein the definition of each group in the general formula (I) is the same as that in the specification. # imgabs0 # 本发明涉及蛋白精氨酸甲基转移酶抑制剂。具体地，本发明涉及通式(I)所示的化合物、其制备方法及含有该化合物的药物组合物，及其作为PRMT5抑制剂的用途。该化合物及含有该化合物的药物组合物可以用于治疗和/或预防与PRMT5活性相关的疾病，例如癌症。其中通式(I)中的各基团的定义与说明书中的定义相同。#imgabs0#
Bibliography:Application Number: CN202410038034