Erdosteine solid dispersible tablet as well as preparation method and application thereof

• Main Authors: SUN SHENGHUA, GUAN YUEQIN, WANG XIULAN
• Format: Patent
• Language: Chinese; English
• Published: 16.07.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of medicines, and particularly relates to an erdosteine solid dispersible tablet as well as a preparation method and application thereof. Comprising the following steps: preparing a solid dispersion solution from erdosteine and a water-soluble polymer dispersion carrier according to a formula ratio, recovering a solvent, freeze-drying the solid dispersion solution in a container on which a diluent I is paved to form a solid state, and crushing the solid dispersion solution into fine powder; and then preparing the erdosteine solid dispersion fine powder, a disintegrating agent, a diluent II, an adhesive, a flow aid, a lubricant and a flavoring agent according to a formula ratio into a solid dispersible tablet, so as to obtain the erdosteine solid dispersible tablet. According to the erdosteine solid dispersible tablet, the water-soluble polymer substance is used as a dispersion carrier, and erdosteine is dispersed in a molecular network skeleton of the water-soluble