Human metapneumovirus vaccine

• Main Authors: CHEN, YINGWEI, MUNDEL STEFAN, ANOSOVA NATALIA, STABLER ANDREAS, GROPP ROMAN, ZHANG LINONG, KIEWKULA STEPHEN, ALAMARES-SAPUE JOSE, STRUGNELL THOMAS, SAMALE SAMIR, DANZ HOLGER, DINAPOLI, JOSEPH, KISHORE MANISH
• Format: Patent
• Language: Chinese; English
• Published: 12.07.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides antigenic pre-fusion hMPV F polypeptides, nucleic acid sequences (e.g., RNA sequences, e.g., mRNA sequences) encoding pre-fusion hMPV F polypeptides, compositions comprising antigenic pre-fusion hMPV F polypeptides, compositions comprising nucleic acid sequences encoding pre-fusion hMPV F polypeptides, and hMPV vaccines. 本披露提供了抗原性融合前hMPV F多肽、编码融合前hMPV F多肽的核酸序列(例如，RNA序列，例如，mRNA序列)、包含抗原性融合前hMPV F多肽的组合物、包含编码融合前hMPV F多肽的核酸序列的组合物和hMPV疫苗。