Antibacterial peptide derived from urechis unicinctus, mutant and application thereof

• Main Authors: LIU GE, HAN JING, SHI NANA, DONG HAOMIAO, YU BO, HUANG DONG, LYU TINGJIN, LI WENHUI, YANG JINLONG, WANG LINDONG, WANG WEIZHONG, SONG KUNZHI, JIAO XUDONG, XU DONG, BU QINGXIANG, ZHANG GUOGUANG, YANG BINGTAO, PANG JINGJING
• Format: Patent
• Language: Chinese; English
• Published: 12.07.2024
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CHEMISTRY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

The invention discloses a natural antibacterial peptide and an application thereof in an antibacterial aspect. The antibacterial peptide disclosed by the invention is derived from urechis unicinctus. A mature peptide sequence of the antibacterial peptide is obtained by searching a urechis unicinctus gene database and screening and analyzing, and the amino acid sequence of the antibacterial peptide is shown as SEQ ID NO: 1 in a sequence table. Through contrastive analysis, the natural antibacterial peptide is obviously different from all known antibacterial peptides in amino acid sequence, and belongs to a novel antibacterial peptide. An antibacterial experiment result shows that the antibacterial peptide has extremely high antibacterial activity on gram-positive bacteria, gram-negative bacteria and fungi, the antibacterial effect is broad-spectrum and efficient, and the antibacterial peptide can be used for preparing drugs for resisting bacteria and inhibiting bacterial growth, preservatives, veterinary drugs