Long-acting antibacterial coagulation osteogenesis-promoting photo-thermal effect hydrogel as well as preparation method and application of long-acting antibacterial coagulation osteogenesis-promoting photo-thermal effect hydrogel

• Main Authors: LIU GUITING, ZHENG HUIYU, HUANG BO, LI MAOJIAO, GUO SHAOYUN
• Format: Patent
• Language: Chinese; English
• Published: 12.07.2024
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

The invention relates to the field of biological materials, in particular to long-acting antibacterial coagulation osteogenesis-promoting photo-thermal effect hydrogel as well as a preparation method and application of the long-acting antibacterial coagulation osteogenesis-promoting photo-thermal effect hydrogel. MXene, dopamine hydrochloride and levofloxacin are subjected to multi-level one-by-one bonding through a chemical reaction to prepare PDMM (at) LF, meanwhile, methacrylic anhydride hyaluronic acid is combined to prepare the photothermal effect hydrogel with the functions of resisting bacteria, coagulating blood and promoting osteogenesis repair, and the hydrogel achieves the functions of resisting bacteria and coagulating blood based on the synergistic effect. The methacrylic anhydride hyaluronic acid gel can realize injectable ultraviolet in-situ gelling, fits a rugged shape in an oral cavity, and realizes wound adaptability. The prepared hydrogel has the effects of resisting bacteria, coagulating b