Specific binding molecules for fibroblast activating protein (FAP)

• Main Authors: LOTZ JONATHAN, KOBURGER INA, GLOSER-BREUNIG MANJA, KATZMANN ANJA, BOSSE-DOENECKE, IVA, BOBOROWSKI, HANNA, BU CKER, HEIKE
• Format: Patent
• Language: Chinese; English
• Published: 09.07.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention relates to novel ubiquitin-derived molecules that specifically bind to fibroblast activation protein (FAP). The present invention also relates to a FAP-binding ubiquitin-derived molecule (# imgabs0 #) protein further comprising a diagnostic or therapeutic active ingredient. Other aspects of the invention encompass such FAP binding proteins for medical use, for example, for diagnostic (including imaging) or therapeutic use of FAP-associated tumors. 本发明涉及特异性结合至成纤维细胞活化蛋白(FAP)的新泛素衍生分子。本发明还涉及进一步包含诊断或治疗活性成分的FAP结合型泛素衍生分子(#imgabs0#)蛋白。本发明的其它方面涵盖了用于医学用途的这类FAP结合蛋白，例如，用于FAP相关肿瘤的诊断(包括成像)或治疗用途。