Application of eltrombopag

The invention relates to an application of a compound eltrombopag as shown in a formula I, a solvate of the eltrombopag or a pharmaceutically acceptable salt of the eltrombopag. The application comprises the following steps: (i) inhibiting binding of TFEb and a CLEAR DNA sequence; (ii) inhibiting th...

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Bibliographic Details
Main Authors YU BIAO, WANG JING, XU PENG, FANG PENGFEI, LIN YUQI, SHI FUCHUN
Format Patent
LanguageChinese
English
Published 05.07.2024
Subjects
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:The invention relates to an application of a compound eltrombopag as shown in a formula I, a solvate of the eltrombopag or a pharmaceutically acceptable salt of the eltrombopag. The application comprises the following steps: (i) inhibiting binding of TFEb and a CLEAR DNA sequence; (ii) inhibiting the transcriptional level of a TFEb downstream lysosome related gene; (iii) inhibiting cell autophagy; (iv) preventing and/or treating tumors. # imgabs0 # 本发明涉及一种式I化合物艾曲波帕、其溶剂化物、或其药学上可接受的盐的用途，包括：(i)抑制TFEb与CLEAR DNA序列的结合；(ii)抑制TFEb下游溶酶体相关基因的转录水平；(iii)抑制细胞自噬；(iv)预防和/治疗肿瘤。#imgabs0#
Bibliography:Application Number: CN20231009586