Manganese-based nanogel, medicine taking nanogel as carrier and anti-sugar, antibacterial and anti-tumor application

• Main Authors: HAN XINYA, OUYANG FENGQI, YAN YIMO, WANG SHUANGSHOU, LI XINYAN, YAN TINGXUAN, WANG YU, HAN YUCHEN, MEI HUANCHUN, SU JIAHAO
• Format: Patent
• Language: Chinese; English
• Published: 05.07.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses a manganese-based nanogel, a medicine taking the nanogel as a carrier and anti-sugar, antibacterial and anti-tumor application, a preparation method of the manganese-based nanogel comprises the following steps: uniformly mixing a proper amount of a KMnO4 aqueous solution and a proper amount of a PAH aqueous solution, standing and reacting for a period of time at normal temperature, and centrifugally washing to obtain MnO2NPs; the preparation method comprises the following steps: uniformly mixing a proper amount of a hyaluronic acid aqueous solution and a sodium alginate aqueous solution, adding a proper amount of N-hydroxysuccinimide, and carrying out an activation reaction for a period of time to obtain a mixed solution; and adding the obtained MnO2NPs into the obtained solution, carrying out ultrasonic stirring, centrifugally collecting precipitates, washing, and freeze-drying to obtain the MnO2 (at) SA/HA nanogel. The nanogel and the medicine taking the manganese-based nanogel as th