Pyridazine derivatives as inhibitors of NLRP3

• Main Authors: GUBA, WOLFGANG, ALANEN TERO ANTERO, HERR STEFAN, AITKEN LINDA SUE, JAESCHKE GEORG, THOM STEPHEN M, MESCH, SCOTT, K, TOSTOV ALEXANDER MIKHAILOVICH, SCHNIEDER CHRISTIAN, STEINER SANDRA, BUSH LAWRENCE A
• Format: Patent
• Language: Chinese; English
• Published: 28.06.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present application relates to pyridazine derivatives of general formula (Ib), # imgabs0 #, to pharmaceutical compositions comprising compounds, and to their use in the treatment of diseases or conditions such as asthma, COPD, Parkinson's disease and Alzheimer's disease. The compounds are useful as inhibitors of NLRP3. 本申请涉及通式(Ib)的哒嗪衍生物，#imgabs0#涉及包含化合物的药物组合物，以及涉及它们在治疗诸如哮喘、COPD、帕金森病和阿尔茨海默病的疾病或病况中的用途。所述化合物用作NLRP3的抑制剂。