Application of haptoglobin in treatment of acute lung injury induced by infrasound

• Main Authors: WANG JIN, LIU MANLING, LI JING, XU SHENGLONG, CAI ZHIGUI
• Format: Patent
• Language: Chinese; English
• Published: 28.06.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of haptoglobin to treatment of acute lung injury induced by infrasound. Aiming at the lung injury caused by infrasound, in addition to strong resonance injury of lung tissues, broken erythrocyte increase can be caused, excessive CFH can be released, then TLR4/NF-kappa B signal channels in lung microvascular endothelial cells are activated, generation of inflammatory cytokines and adhesion and aggregation of leukocytes are triggered, endogenous scavenger haptoglobin of CFH is subjected to intravenous injection, and the endogenous scavenger haptoglobin of CFH is subjected to intravenous injection; the compound can effectively reduce excessive release of CFH caused by infrasound, further inhibits activation of a TLR4/NF-kappa B signal channel and reduces adhesion of white blood cells, thereby reducing the severity of lung injury caused by infrasound. 本发明公开了触珠蛋白治疗次声诱导的急性肺损伤的应用。针对次声导致肺损伤中除了引起强烈共振损伤肺组织以外，还能造成破碎红细胞增多并释放过量CFH，进而激活肺微血管内皮细胞中TLR4/NF-κB信号通路，引发炎症细胞因子的产生和白细胞的粘附、聚集，采用静脉注射