Synthesis method of high-optical-purity litamilast

The invention discloses a synthesis method of high optical purity litamilast. And reacting the litamilast intermediate F with an organic acid in the presence of an acid catalyst, and removing benzyl to prepare litamilast. The litamilast prepared by the method has fewer chemical impurities and chiral...

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Bibliographic Details
Main Authors JIANG CHUNYANG, LI HUI, XIE JUN, SHU HAIYING, XIAO FANHUA
Format Patent
LanguageChinese
English
Published 25.06.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a synthesis method of high optical purity litamilast. And reacting the litamilast intermediate F with an organic acid in the presence of an acid catalyst, and removing benzyl to prepare litamilast. The litamilast prepared by the method has fewer chemical impurities and chiral impurities, and meanwhile, the method is simple in process route, low in cost and suitable for industrial production. 本发明公开了一种高光学纯度立他司特的合成方法；立他司特中间体F在酸性催化剂存在下与有机酸进行反应，脱去苄基，制备得到立他司特。该方法制备得到的立他司特化学杂质和手性杂质较少，同时该方法工艺路线简单、成本低廉、适合工业化生产。
Bibliography:Application Number: CN202211662997